Protein Details: Glycine receptor subunit alpha-2

Protein ID

ICDB_Pro_0416

Protein Name

Glycine receptor subunit alpha-2

Gene Name

Glra2

Organism

Rattus norvegicus (Rat)

Length

452 amino acids

AlphaFoldDB

AF-P22771-F1-model_v4.pdb

Function

Sequence

MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

194;226;228;236-241;249

Disease

Location

The alpha-2* subunit isoform is present in neonatal rats; but not in older animals. Isoform Alpha-2* and isoform Alpha-2B are detected in embryonic and neonatal brain. At later postnatal stages; isoform Alpha-2* levels greatly decrease while isoform Alpha-2B is barely detectable.